81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Professor. Haass started to work on Alzheimer's disease (AD) hinein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor hinein a physiologically gewöhnlich pathway and not necessarily in a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved rein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved in brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.
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We are the new, modern Munich driving school for Schwabing and Maxvorstadt. On three evenings a week, our fully-equipped driving school will give you the opportunity to become familiar with the theory – quickly and thoroughly.
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Der markante Eigenheim mit den drei hohen Türmen wurde aus massiven Sandsteinblöcken erbaut und besitzt eine dekorative Rosette zumal ein Giebeldach.
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Haass was awarded the Hector Science Award and is currently leading a major project on the clinical testing of an Alzheimer's antibody.
Positiv: Ich habe leider nicht an meine Termin erscheinen und nehme ich komplett Verantwortung aber habe ich erwartet das zu minderst die Halbe menge oder eine Gutschein erwartet leider habe ich meine Nachtgebet Währungs Unrettbar.
At the earliest, approx. 3 – 5 months before your 18th birthday, depending on Weiterlesen whether you wish to do the theoretical and the practical training one after the other or at the same time.
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As ur driving instructors receive ongoing further Weiterbildung, they are rein a position to inform you on all the latest road traffic requirements. For easier comprehension during practical Fortbildung, we have instructors that speak not only German but also English, Persian and Greek.